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Nevertheless, exactly the same focus of Gain although not other CB1R agonists, improves intracellular Ca2+ focus by using Gq/11 protein in transfected HEK-293 cells and cultured hippocampal neurons with endogenous receptor expression [93]. Also, in mice hippocampal slices, CB1R expressed in astrocytes is coupled to Gq/eleven, raises intracellular C
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